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The short answer is, beevile it or not, YES. In fact, that's what the Mavic Speedcity wheelset is made for. Just keep tires thin.How is it possible? Because 700 C and 26 are just nominal diameters for tires.The true (bead seat) diameter for a 26 rim is 559 mm. A 26 2.20 tire will add about 57 mm on each side. That gives us an outer diameter of 673 mm. But a mountain frame also needs additional clearance for mud. For that reason, a cross country mountain bike frame usually has a total clearance of about 700 mm.For a 700 C rim, the true diameter is 622 mm. A 700 25C (25-622) tire will add about 25 mm on each side, making a total diameter of 672 mm. In other words, a thin tire on a 700 C wheel has about the same diameter as a big 26 cross country tire.If you can only fit a 26 2.1 mountain bike tire, you will need a 700 20C (20-622) road tire.